Segalés Coma, Joaquim

Principal Investigator - Endemic Swine Viruses

Latest
Publications

  • Anti-SARS-CoV-2 antibodies from severe COVID-19 individuals or S2 immunizations do not worsen disease in hamsters

    Pedreño-Lopez, N; Tarrés-Freixas, F; Usai, C; Raïch-Regué, D; Benet, S; Ainsua-Enrich, E; Carabelli, J; Pradenas, E; Avila-Nieto, C; Roca, N;...

    Communications Biology . 2025 10.1038/s42003-025-09034-3
  • Concurrent histological lesions and molecular detection of porcine circovirus 3 in pigs with skeletal abnormalities and humpy-back posture

    Rosato, Giuliana; Makoni, Grace M; Cobos, Alex; Sibila, Marina; Segales, Joaquim; Graage, Robert; Kummerlen, Dolf; Echtermann, Thomas; Aeberhard,...

    Veterinary Pathology. 2025 10.1177/03009858251386914
  • Automated pixel-based quantification of porcine circovirus 2 genome in formalin-fixed, paraffin-embedded tissues using in situ hybridisation

    Sagrera, Monica; Cobos, Alex; Garza-Moreno, Laura; Perez, Monica; Garcia-Buendia, Gema; Huerta, Eva; Llorens, Anna Maria; Espigares, David; Sibila,...

    Frontiers In Veterinary Science. 2025 10.3389/fvets.2025.1609897
  • Central TYK2 inhibition identifies TYK2 as a key neuroimmune modulator

    Molitor, Tyler P; Hayashi, Genki; Lin, Mei-Yao; Dunn, Carissa J; Peterson, Nathan G; Poston, Robert G; Kurnellas, Michael P; Traver, David A; Patel,...

    Proceedings Of The National Academy Of Sciences Of The United States Of America. 2025 10.1073/pnas.2422172122
  • Resistance to SARS-CoV-2 infection in camelid nasal organoids is associated with lack of ACE2 expression

    Breugem, Tim I; Riesebosch, Samra; Schipper, Debby; Mykytyn, Anna Z; van den Doel, Petra; Segales, Joaquim; Lamers, Mart M; Haagmans, Bart L

    Npj Viruses. 2024 10.1038/s44298-024-00054-0
  • Resistance to SARS-CoV-2 infection in camelid nasal organoids is associated with lack of ACE2 expression

    Tim I. Breugem; Samra Riesebosch; Debby Schipper; Anna Z. Mykytyn; Petra van den Doel; Joaquím Segalés; Mart M. Lamers; Bart L. Haagmans

    Npj Viruses. 2024 10.1038/s44298-024-00054-0
  • Quantification of camelid cytokine mRNA expression in PBMCs by microfluidic qPCR technology

    Rodon, J; Te, NG; Ballester, M; Segalés, J; Vergara-Alert, J; Bensaid, A

    Developmental And Comparative Immunology. 2023 10.1016/j.dci.2023.105061
  • Enhanced replication fitness of MERS-CoV clade B over clade A strains in camelids explains the dominance of clade B strains in the Arabian Peninsula

    Te, N; Rodon, J; Pérez, M; Segalés, J; Vergara-Alert, J; Bensaid, A

    Emerging Microbes & Infections. 2022 10.1080/22221751.2021.2019559
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and humoral responses against different variants of concern in domestic pet animals and stray cats from North-Eastern Spain

    Fernandez-Bastit, L; Marfil, S; Pradenas, E; Valle, R; Roca, N; Rodon, J; Pailler-García, L; Trinité, B; Parera, M; Noguera-Julian, M; Martorell,...

    Transboundary And Emerging Diseases. 2022 10.1111/tbed.14714
  • Descriptive analyses of maternally-derived antibody levels against porcine circovirus 2 (PCV-2) in 3-and 21-day-old piglets from farms of four European countries using different vaccination protocols in sows

    Sibila, M; Llorens, A; Huerta, E; Fablet, C; Faderl, M; Ferrari, L; Rose, N; Palzer, A; Martelli, P; Venegas-Vargas, MC; Fredrickson, D; Taylor, L;...

    Porcine Health Management. 2022 10.1186/s40813-022-00284-9
  • Evaluation of alpaca tracheal explants as an ex vivo model for the study of Middle East respiratory syndrome coronavirus (MERS-CoV) infection

    Te, N; Rodon, J; Creve, R; Perez, M; Segales, J; Vergara-Alert, J; Bensaid, A

    Veterinary Research. 2022 10.1186/s13567-022-01084-3
  • Evolution of Swine Influenza Virus H3N2 in Vaccinated and Nonvaccinated Pigs after Previous Natural H1N1 Infection

    López-Valiñas, A; Baioni, L; Córdoba, L; Darji, A; Chiapponi, C; Segalés, J; Ganges, L; Nunez, JI

    Viruses-Basel. 2022 10.3390/v14092008
  • Susceptibility of Domestic Goat (Capra aegagrus hircus) to Experimental Infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) B.1.351/Beta Variant

    Fernández-Bastit, L; Roca, N; Romero-Durana, M; Rodon, J; Cantero, G; García, O; López, C; Pérez, M; López, R; Carrillo, J; Izquierdo-Useros, N;...

    Viruses-Basel. 2022 10.3390/v14092002
  • Efficacy Studies of a Trivalent Vaccine Containing PCV-2a, PCV-2b Genotypes and Mycoplasma hyopneumoniae When Administered at 3 Days of Age and 3 Weeks Later against Porcine Circovirus 2 (PCV-2) Infection

    Pleguezuelos, P; Sibila, M; Cuadrado-Matías, R; López-Jiménez, R; Pérez, D; Huerta, E; Pérez, M; Correa-Fiz, F; Mancera-Gracia, JC; Taylor, LP;...

    Vaccines. 2022 10.3390/vaccines10081234
  • Middle East respiratory syndrome coronavirus infection in camelids

    Te, N; Ciurkiewicz, M; van den Brand, JMA; Rodon, J; Haverkamp, AK; Vergara-Alert, J; Bensaid, A; Haagmans, BL; Baumgartner, W; Segalés, J

    Veterinary Pathology. 2022 10.1177/03009858211069120
  • Chronological brain lesions after SARS-CoV-2 infection in hACE2-transgenic mice

    Vidal, E; López-Figueroa, C; Rodon, J; Pérez, M; Brustolin, M; Cantero, G; Guallar, V; Izquierdo-Useros, N; Carrillo, J; Blanco, J; Clotet, B;...

    Veterinary Pathology. 2022 10.1177/03009858211066841
  • Protective efficacy of an RBD-based Middle East respiratory syndrome coronavirus (MERS-CoV) particle vaccine in llamas

    Rodon, J; Mykytyn, AZ; Cantero, G; Albulescu, IC; Bosch, BJ; Brix, A; Audonnet, JC; Bensaid, A; Vergara-Alert, J; Haagmans, BL; Segalés, J

    One Health Outlook. 2022 10.1186/s42522-022-00068-9
  • Heterogeneous Infectivity and Pathogenesis of SARS-CoV-2 Variants Beta, Delta and Omicron in Transgenic K18-hACE2 and Wildtype Mice

    Tarrés-Freixas, F; Trinité, B; Pons-Grífols, A; Romero-Durana, M; Riveira-Muñoz, E; Avila-Nieto, C; Pérez, M; Garcia-Vidal, E; Perez-Zsolt, D;...

    Frontiers In Microbiology. 2022 10.3389/fmicb.2022.840757
  • Unraveling the antiviral activity of plitidepsin against SARS-CoV-2 by subcellular and morphological analysis

    Sachse, M; Tenorio, R; Castro, IFD; Munoz-Basagoiti, J; Perez-Zsolt, D; Raich-Regu, D; Rodon, J; Losada, A; Avil, P; Cuevas, C; Paredes, R; Segales,...

    Antiviral Research. 2022 10.1016/j.antiviral.2022.105270
  • Impact of maternally derived immunity on immune responses elicited by piglet early vaccination against the most common pathogens involved in porcine respiratory disease complex

    Martínez-Boixaderas, N; Garza-Moreno, L; Sibila, M; Segalés, J

    Porcine Health Management. 2022 10.1186/s40813-022-00252-3
  • Revisiting Porcine Circovirus Disease Diagnostic Criteria in the Current Porcine Circovirus 2 Epidemiological Context

    Segalés, J; Sibila, M

    Veterinary Sciences . 2022 10.3390/vetsci9030110
  • Clinical course impacts early kinetics, magnitude, and amplitude of SARS-CoV-2 neutralizing antibodies beyond 1 year after infection

    Pradenas, E; Trinité, B; Urrea, V; Marfil, S; Tarres-Freixas, F; Ortiz, R; Rovirosa, C; Rodon, J; Vergara-Alert, J; Segalées, J; Guallar, V;...

    Cell Reports Medicine . 2022 10.1016/j.xcrm.2022.100523
  • Rapid SARS-CoV-2 Inactivation in a Simulated Hospital Room Using a Mobile and Autonomous Robot Emitting Ultraviolet-C Light

    Lorca-Oró, C; Vila, J; Pleguezuelos, P; Vergara-Alert, J; Rodon, J; Majó, N; López, S; Segalés, J; Saldaña-Buesa, F; Visa-Boladeras, M;...

    Journal Of Infectious Diseases. 2022 10.1093/infdis/jiab551
  • Exploratory Study of the Frequency of Detection and Tissue Distribution of Porcine Circovirus 3 (PCV-3) in Pig Fetuses at Different Gestational Ages

    Ruiz, A; Saporiti, V; Huerta, E; Balasch, M; Segalés, J; Sibila, M

    Pathogens. 2022 10.3390/pathogens11020118
  • Comprehensive Analysis of Codon Usage Patterns in Chinese Porcine Circoviruses Based on Their Major Protein-Coding Sequences

    Feng, H; Segalés, J; Wang, FY; Jin, QY; Wang, AP; Zhang, GP; Franzo, G

    Viruses-Basel. 2022 10.3390/v14010081
  • Piglet innate immune response to Streptococcus suis colonization is modulated by the virulence of the strain

    Neila-Ibáñez, C; Brogaard, L; Pailler-García, L; Martínez, J; Segalés, J; Segura, M; Heegaard, PMH; Aragon, V

    Veterinary Research. 2021 10.1186/s13567-021-01013-w
  • First Detection of SARS-CoV-2 Delta (B.1.617.2) Variant of Concern in a Dog with Clinical Signs in Spain

    Fernandez-Bastit, L; Rodon, J; Pradenas, E; Marfil, S; Trinite, B; Parera, M; Roca, N; Pou, A; Cantero, G; Lorca-Oro, C; Carrillo, J;...

    Viruses-Basel. 2021 10.3390/v13122526
  • Neoplastic lesions in domestic pigs detected at slaughter: literature review and a 20-year review (1998-2018) of carcass inspection in Catalonia

    Morey-Matamalas, A; Vidal, E; Martínez, J; Alomar, J; Ramis, A; Marco, A; Domingo, M; Segalés, J

    Porcine Health Management. 2021 10.1186/s40813-021-00207-0
  • A case of uterine inclusion cysts in a sow

    Ruiz-Riera, E; Nofrarias, M; Martí-Garcia, B; Domingo, M; Segalés, J; Vidal, E

    Porcine Health Management. 2021 10.1186/s40813-021-00237-8
  • Multisystemic lymphoplasmacytic inflammation associated with PCV-3 in wasting pigs

    Alomar, J; Saporiti, V; Pérez, M; Gonçalvez, D; Sibila, M; Segalés, J

    Transboundary And Emerging Diseases. 2021 10.1111/tbed.14260
  • Porcine circovirus 3 (PCV-3) as a causal agent of disease in swine and a proposal of PCV-3 associated disease case definition

    Saporiti, V; Franzo, G; Sibila, M; Segalés, J

    Transboundary And Emerging Diseases. 2021 10.1111/tbed.14204
  • Identification and Characterization of Swine Influenza Virus H1N1 Variants Generated in Vaccinated and Nonvaccinated, Challenged Pigs

    López-Valiñas, A; Sisteré-Oró, M; López-Serrano, S; Baioni, L; Darji, A; Chiapponi, C; Segalés, J; Ganges, L; Nunez, JI

    Viruses-Basel. 2021 10.3390/v13102087
  • Monitoring Natural SARS-CoV-2 Infection in Lions (Panthera leo) at the Barcelona Zoo: Viral Dynamics and Host Responses

    Fernández-Bellon, H; Rodon, J; Fernández-Bastit, L; Almagro, V; Padilla-Solé, P; Lorca-Oró, C; Valle, R; Roca, N; Grazioli, S; Trogu, T; Bensaid,...

    Viruses-Basel. 2021 10.3390/v13091683
  • Genotyping of Porcine Circovirus 2 (PCV-2) in Vaccinated Pigs Suffering from PCV-2-Systemic Disease between 2009 and 2020 in Spain

    Sibila, M; Rocco, C; Franzo, G; Huerta, E; Domingo, M; Núñez, JI; Segalés, J

    Pathogens. 2021 10.3390/pathogens10081016
  • Pigs are not susceptible to SARS-CoV-2 infection but are a model for viral immunogenicity studies

    Vergara-Alert, J; Rodon, J; Carrillo, J; Te, N; Izquierdo-Useros, N; de la Concepción, MLR; Avila-Nieto, C; Guallar, V; Valencia, A; Cantero, G;...

    Transboundary And Emerging Diseases. 2021 10.1111/tbed.13861
  • Effect of Edema Disease Vaccination on Mortality and Growth Parameters in Nursery Pigs in a Shiga Toxin 2e Positive Commercial Farm

    Mesonero-Escuredo, S; Morales, J; Mainar-Jaime, RC; Díaz, G; Arnal, JL; Casanovas, C; Barrabés, S; Segalés, J

    Vaccines. 2021 10.3390/vaccines9060567
  • Previous SARS-CoV-2 Infection Increases B.1.1.7 Cross-Neutralization by Vaccinated Individuals

    Trinité, B; Pradenas, E; Marfil, S; Rovirosa, C; Urrea, V; Tarrés-Freixas, F; Ortiz, R; Rodon, J; Vergara-Alert, J; Segalés, J; Guallar, V;...

    Viruses-Basel. 2021 10.3390/v13061135
  • Type I and III IFNs produced by the nasal epithelia and dimmed inflammation are features of alpacas resolving MERS-CoV infection

    Te, N; Rodon, J; Ballester, M; Pérez, M; Pailler-García, L; Segalés, J; Vergara-Alert, J; Bensaid, A

    Plos Pathogens. 2021 10.1371/journal.ppat.1009229
  • Effect of spray-drying and ultraviolet C radiation as biosafety steps for CSFV and ASFV inactivation in porcine plasma

    Blázquez, E; Rodríguez, C; Ródenas, J; Rosell, R; Segalés, J; Pujols, J; Polo, J

  • Exploratory field study on the effects of porcine circovirus 2 (PCV-2) sow vaccination at different physiological stages mimicking blanket vaccination

    Pleguezuelos, P; Sibila, M; Cuadrado, R; López-Jiménez, R; Pérez, D; Huerta, E; Llorens, AM; Núñez, JI; Segalés, J; López-Soria, S

    Porcine Health Management. 2021 10.1186/s40813-021-00213-2
  • Increasing breast milk betaine modulates Akkermansia abundance in mammalian neonates and improves long-term metabolic health

    Ribo, S; Sánchez-Infantes, D; Martinez-Guino, L; García-Mantrana, I; Ramon-Krauel, M; Tondo, M; Arning, E; Nofrarías, M; Osorio-Conles, O;...

    Science Translational Medicine. 2021 10.1126/scitranslmed.abb0322
  • Identification of Plitidepsin as Potent Inhibitor of SARS-CoV-2-Induced Cytopathic Effect After a Drug Repurposing Screen

    Rodon, J; Muñoz-Basagoiti, J; Perez-Zsolt, D; Noguera-Julian, M; Paredes, R; Mateu, L; Quiñones, C; Perez, C; Erkizia, I; Blanco, I; Valencia, A;...

    Frontiers In Pharmacology. 2021 10.3389/fphar.2021.646676
  • Review of the speculative role of co-infections in Streptococcus suis-associated diseases in pigs

    Obradovic, MR; Segura, M; Segalés, J; Gottschalk, M

    Veterinary Research. 2021 10.1186/s13567-021-00918-w
  • Stable neutralizing antibody levels 6 months after mild and severe COVID-19 episodes

    Pradenas, E; Trinité, B; Urrea, V; Marfil, S; Avila-Nieto, C; de la Concepción, MLR; Tarrés-Freixas, F; Pérez-Yanes, S; Rovirosa, C;...

    Med (N Y). 2021 10.1016/j.medj.2021.01.005
  • Porcine Circovirus 3 Detection in Aborted Fetuses and Stillborn Piglets from Swine Reproductive Failure Cases

    Saporiti, V; Valls, L; Maldonado, J; Perez, M; Correa-Fiz, F; Segalés, J; Sibila, M

    Viruses-Basel. 2021 10.3390/v13020264
  • SARS-CoV-2 infection elicits a rapid neutralizing antibody response that correlates with disease severity

    Trinité, B; Tarrés-Freixas, F; Rodon, J; Pradenas, E; Urrea, V; Marfl, S; de la Concepción, MLR; Avila-Nieto, C; Aguilar-Gurrieri, C; Barajas, A;...

    Scientific Reports. 2021 10.1038/s41598-021-81862-9
  • Protection against reinfection with D614-or G614-SARS-CoV-2 isolates in golden Syrian hamster

    Brustolin, M; Rodon, J; de la Concepción, MLR; Avila-Nieto, C; Cantero, G; Pérez, M; Te, N; Noguera-Julián, M; Guallar, V; Valencia, A; Roca, N;...

    Emerging Microbes & Infections. 2021 10.1080/22221751.2021.1913974
  • Porcine Circovirus 2 Genotypes, Immunity and Vaccines: Multiple Genotypes but One Single Serotype

    Franzo, G; Segalés, J

    Pathogens. 2020 10.3390/pathogens9121049
  • Cross-neutralization activity against SARS-CoV-2 is present in currently available intravenous immunoglobulins

    Díez, JM; Romero, C; Vergara-Alert, J; Belló-Perez, M; Rodon, J; Honrubia, JM; Segalés, J; Sola, I; Enjuanes, L; Gajardo, R

    Immunotherapy. 2020 10.2217/imt-2020-0220
  • Detection and genotyping of Porcine circovirus 2 (PCV-2) and detection of Porcine circovirus 3 (PCV-3) in sera from fattening pigs of different European countries

    Saporiti, V; Huerta, E; Correa-Fiz, F; Liesner, BG; Duran, O; Segalés, J; Sibila, M

    Transboundary And Emerging Diseases. 2020 10.1111/tbed.13596
  • Animal models for COVID-19

    Muñoz-Fontela, C; Dowling, WE; Funnell, SGP; Gsell, PS; Riveros-Balta, AX; Albrecht, RA; Andersen, H; Baric, RS; Carroll, MW; Cavaleri, M; Qin, C;...

  • Porcine circovirus 2 (PCV2) population study in experimentally infected pigs developing PCV2-systemic disease or a subclinical infection

    Correa-Fiz, F; Franzo, G; Llorens, A; Huerta, E; Sibila, M; Kekarainen, T; Segalés, J

    Scientific Reports. 2020 10.1038/s41598-020-74627-3
  • Detection of SARS-CoV-2 in a cat owned by a COVID-19-affected patient in Spain

    Segalés, J; Puig, M; Rodon, J; Avila-Nieto, C; Carrillo, J; Cantero, G; Terrón, MT; Cruz, S; Parera, M; Noguera-Julián, M; Izquierdo-Useros, N;...

    Proceedings Of The National Academy Of Sciences Of The United States Of America. 2020 10.1073/pnas.2010817117
  • Commercial feed containing porcine plasma spiked with African swine fever virus is not infective in pigs when administered for 14 consecutive days

    Blázquez, E; Pujols, J; Segalés, J; Rodríguez, F; Crenshaw, J; Rodríguez, C; Ródenas, J; Polo, J

  • Biosafety steps in the manufacturing process of spray-dried plasma: a review with emphasis on the use of ultraviolet irradiation as a redundant biosafety procedure

    Blazquez, E; Rodríguez, C; Ródenas, J; Segalés, J; Pujols, J; Polo, J

    Porcine Health Management. 2020 10.1186/s40813-020-00155-1
  • Frequency of Detection and Phylogenetic Analysis of Porcine circovirus 3 (PCV-3) in Healthy Primiparous and Multiparous Sows and Their Mummified Fetuses and Stillborn

    Saporiti, V; Martorell, S; Cruz, TF; Klaumann, F; Correa-Fiz, F; Balasch, M; Sibila, M; Segalés, J

    Pathogens. 2020 10.3390/pathogens9070533
  • Lack of Porcine circovirus 4 Genome Detection in Pig Samples from Italy and Spain

    Franzo, G; Ruiz, A; Grassi, L; Sibila, M; Drigo, M; Segalés, J

    Pathogens. 2020 10.3390/pathogens9060433
  • Comparison of Mycoplasma hyopneumoniae and porcine circovirus 2 commercial vaccines efficacy when applied separate or combined under experimental conditions

    Sibila, M; Guevara, G; Cuadrado, R; Pleguezuelos, P; Pérez, D; de Rozas, AP; Huerta, E; Llorens, A; Valero, O; Pérez, M; López, C; Krejci, R;...

    Porcine Health Management. 2020 10.1186/s40813-020-00148-0
  • Detection of Porcine Circovirus 3 in Wildlife Species in Spain

    Czyzewska-Dors, E; Núñez, JI; Saporiti, V; Huerta, E; Riutord, C; Cabezón, O; Segalés, J; Sibila, M

    Pathogens. 2020 10.3390/pathogens9050341
  • Genotyping porcine circovirus 3 (PCV-3) Nowadays: Does it make sense?

    Franzo, G; Delwart, E; Fux, R; Hause, B; Su, S; Zhou, JY; Segalés, J

    Viruses-Basel. 2020 10.3390/v12030265
  • Use of the informational spectrum methodology for rapid biological analysis of the novel coronavirus 2019-nCoV: Prediction of potential receptor, natural reservoir, tropism and therapeutic/vaccine target

    Veljkovic V; Vergara-Alert J; Segalés J; Paessler S

    F1000research. 2020 10.12688/f1000research.22149.1
  • Cutaneous apocrine cystomatosis in three slaughter-aged pigs

    López-Figueroa, C; Domingo, M; Martí, B; Vidal, E; Segalés, J

    Journal Of Veterinary Diagnostic Investigation. 2020 10.1177/1040638719894553
  • Similar frequency of Porcine circovirus 3 (PCV-3) detection in serum samples of pigs affected by digestive or respiratory disorders and age-matched clinically healthy pigs

    Saporiti, V; Cruz, TF; Correa-Fiz, F; Núñez, JI; Sibila, M; Segalés, J

    Transboundary And Emerging Diseases. 2020 10.1111/tbed.13341
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